Obesity is a major risk factor for the development of cardiovascular complications. It is estimated that by 2030, half of Americans will be obese. Thus, research in this field is urgently needs to help control obesity-derived cardiovascular complications. Our research focuses on understanding how metabolic conditions alter key molecular mediators that are essential for maintaining vascular integrity. These studies focus on identifying potential targets that will alleviate vascular complications such as arterial stiffness and hypertension. Moreover, Sepulveda’s lab became interested in investigating sex difference in the context of obesity and vascular complications. To address these questions, the lab utilize an integrative approach that includes pre-clinical animal models of obesity and type 2 diabetes molecular, transgenic mice, cellular /molecular/ and physiological approaches. Sepulveda’s lab long-term goal is to convert basic sciences discoveries into development of therapeutic strategies for preventing or halting the progression of vascular complications in diabetes.
OBESITY-RELATED VASCULAR COMPLICATIONS
THYROID HORMONE AND VASCULAR REGULATION